Many neuroracliologic, neurochemical, neurophysiological studies examining lateralization characteristics and neurologic signs in schizophrenia have been reported. However a research conceming boh of this themes has not been demonstrated in the literature reached so far. With this intent, we evaluated the lateralization findings of 40 patients who show right handed dominance according to "Annet's Questionnaire" and who are diagnosed as "Chronic Schizophrenia" according to DSM III-R and as "Mixed and Negative Schizophrenia" according w Andreasen's Rating Scale of Negative-Positive Symptoms (SANS, SAPS). Our control group consisted of 20 heathy patients. Lateralization findings were evaluated simply by hand, eye and foot preference tests and dichotic auditory tests. Buchanon-Henrich's Neurologic Rating Scale (NES) was applied to each subject and existance and dimensions of a probable relationship was examined. Results showed that clusters of right preference was evidently small in number of patients (p<0.005) and the controls whose preferences clustered as right had significantly less soft neurological signs (NES score), soft neurological signs were significantly higher in the higher in the patient group, no differences were found related with any variables between negative and mixed types. As a conclıısion it has been demonstrated that among the subjects who all right handed, schizophrenic patients can be dıfferentiated from the control group by cross dominance which is identified by a deviation in one of the preferences. This finding is parallel with an increment in soft neurologic signs. Control subjects who show cross dominance also have an increase in soft neurologic signs, however; both cross dominance and sof neurologic signs are evidently higher in the patients. As a summary it has been interpreted that increment in neurologic signs is associated with an alteration in cerebral specialization.