Hemorrhagic transformation or hemorrhagic infarction is still an important problem at neurology practise. Recently, the predictive value of early hypodensity, seen at cranial computerized tomography, in the evaluation of hemorrhagic infarction observed in the early period of ischemic stroke is stated in literature. In this study, we aimed to evaluate the role of early hypodensity in predicting hemorrhagic infarction. We evaluated 126 ischemic patients with early cranial computerized tomography within 6 hours of stroke. We compared the early the early hypodensity findings in 62 patients with hemorrhagic transformation, verified with control cranial computerized tomography and 64 patients without hemorrhagic transformation. Chi-square test was used for statistical analysis. Early hypodensity sign was found at 38 (61.2 %) hemorrhagic infarction cases and 20 (31.5 %) of cases with non-hemorrhagic infarction. Early hypodensity sign at hemorrhagic infarction cases was significantly higher than the group who did not have hemorrhagic infarction (p=0.001). Conclusively, early hypodensity sign seen at the early period cranial computerized tomography is a predictive factor in the evaluation of hemorrhagic transformation and this sign may have a value to determine a therapy protocol.