Gliomas are the largest group of CNS tumours derivina from the neuroglia. Glioblastoma multiorme is the commonest primary malignant brain tumour and has the poorest prognosis. Despite the advanced surgical and radiotherapy techniques, five year survival rate is less then 5. Ausman, in 1970, emphasized the importance of genetric. immunologic and potential chemotherapeutic approaches in the treatment of primary malignant brain tumours, and exactly for 20 years these approaches have been tested on experimental glioma models. In this study. experimental C6 glioma model was examined for technique and migration criterions. 16 rats were used. C6 glioma cells were implanted into the left frontal region of the rat brains. The rats were seperated into 4 groups according to the amount of cells implanted. In each group there were 2 Wistar and 2 Sprague-Dawley rats. Tumour formation was directly proportional to the amount of cell implanted. Tumour cells were seen in forms of a layer around the brain stern and temporo-basal region far from the implantation area. These findings indicated the invasion and migration.

As a result, wc believe that with the C6 rat glioma model that was invastigated in the research laboratory of our institution, proved to be a satisfactory animal model to study certain therapeutic aspects of malignant glial tumors.